Cardiovascular, Renal and Metabolism (CVRM), part of BioPharmaceuticals, forms one of AstraZeneca’s main disease areas and is a key growth driver for the Company. By following the science to understand more clearly the underlying links between the heart, kidneys, liver and pancreas, AstraZeneca is investing in a portfolio of medicines for organ protection by slowing or stopping disease progression, and ultimately paving the way towards regenerative therapies. The Company’s ambition is to improve and save the lives of millions of people, by better understanding the interconnections between CVRM diseases and targeting the mechanisms that drive them, so we can detect, diagnose and treat people earlier and more effectively.

AstraZeneca
AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca’s innovative medicines are sold in more than 125 countries and used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on social media @AstraZeneca

Boehringer Ingelheim, founded in 1885 and family-owned ever since, is working on breakthrough therapies that transform lives, now and in generations to come. As a leading research-driven biopharmaceutical company, Boehringer Ingelheim creates value through innovation in areas of high unmet medical need.

Among other disease areas, Boehringer Ingelheim is concentrating research efforts and investment in cardio–renal–metabolic (CRM) diseases – a group of interconnected conditions affecting the heart, kidneys, and the metabolic system. More than 1 billion people worldwide are living with CRM diseases such as obesity, type 2 diabetes, chronic kidney disease, liver disease, heart failure, and cardiovascular disease. Despite significant improvements in life expectancy over the last decades, CRM diseases are still amongst the leading causes of death globally – and their prevalence is expected to continue to rise.

Due to the interconnectivity of the CRM systems, people are often impacted by multiple health conditions, posing an increased physical and emotional burden. Boehringer Ingelheim is addressing these challenges by taking a holistic approach to the management of CRM conditions. While the onset of one disease can increase the risk of developing another, improvement in one disease can have additional benefits in others. Considering this, Boehringer Ingelheim is exploring synergies between disease mechanisms and pathways to deliver the next wave of innovative therapies aiming to restore the balance between the interconnected CRM systems, reducing the risk of serious complications, thereby improving the outcomes of people living with CRM diseases.

Our legacy in cardio–renal–metabolic diseases
Boehringer Ingelheim’s significant expertise and leadership in CRM diseases is evidenced by our track record of excellence in research and landmark clinical trials, which have resulted in important achievements in recent years, especially in thromboembolic diseases, type 2 diabetes, heart failure, and chronic kidney disease. Boehringer Ingelheim developed the first pharmacotherapy for type 2 diabetes that demonstrated substantial cardiovascular benefits in a cardiovascular outcomes trial. This has paved the way for a shift towards a holistic view on CRM diseases, including heart failure and chronic kidney disease. By building on our long-standing legacy and deep knowledge, Boehringer Ingelheim is developing a portfolio of novel compounds that address CRM conditions with enduring high unmet medical need. One prominent CRM condition that is being researched is obesity, a metabolic and multifactorial disease at the center of CRM diseases.

https://www.boehringer-ingelheim.com/

Currax Pharmaceuticals LLC is a specialty biopharmaceutical company focused on enhancing the lives of patients worldwide by expanding access to life-changing medications that treat diseases such as obesity. Currax distributes a range of both branded and generic pharmaceutical products. For more information, please visit our website: www.curraxpharma.com

Rhythm Pharmaceuticals is a commercial-stage biopharmaceutical company committed to transform the lives of patients and their families living with hyperphagia and severe obesity caused by rare melanocortin-4 receptor (MC4R) pathway diseases by rapidly advancing care and precision medicines addressing the root cause. Our science is dedicated to the understanding of hyperphagia and severe obesity caused by genetic variants leading to an impaired MC4R pathway. For more information about the science and our solutions, please visit our website: www.path4hcps.com

COSMED, an Italian company established in 1980, designs, manufactures, and sells worldwide diagnostic medical devices to assess Cardiopulmonary and Metabolic functions and Body Composition, addressing the needs of Health Care and Research public and private organizations and professionals operating in the Hospital, Primary Care, Sport Science and Human Performance, and Health and Wellness markets.

COSMED medical devices are grouped into five Product Lines:

• Cardiopulmonary Exercise Testing
• Indirect Calorimetry
• Pulmonary Function Testing
• Spirometry
• Body Composition

COSMED employs worldwide more than 200 people, with over 20 mechanical, electronic and software engineers engaged in R&D. Its headquarters are in Rome (Italy) and it has two plants located in Italy and USA.

Direct operations, through its fully owned subsidiaries, are held in Australia, Denmark, France, Germany, Hong Kong, Netherland, Switzerland, and USA, and with over 80 Business Partners, are covered more than 100 countries.

Accuracy, reliability and duration of diagnostic medical devices and the innovative software platform OMNIA, worldwide superior customer care, first class technical support, effective training services, along with regular software updates and guaranteed availability of original spare parts and supply of consumables, guarantee COSMED customers to preserve and exploit their investments over time.

QPS is a GLP/GCP-compliant global full-service CRO providing discovery, bioanalysis, preclinical, and clinical drug development services since 1995. We accelerate pharmaceutical breakthroughs by delivering custom-built research services in Pharmacology, Toxicology, DMPK, Bioanalysis, Cell Therapy Products, Clinical Trials, and Clinical Research Services. With a proven track record conducting clinical trials for drugs such as GLP-1, GLP-1R, GIP, GCG, and GCGR agonists, as well as combinations of those products, QPS ensures high-quality standards, technical expertise, and a flexible research approach. We prioritize client satisfaction with our turnkey laboratories, Phase I clinical facilities, and a robust late-phase clinical CRO services team.